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KMID : 0545120190290020179
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Journal of Microbiology and Biotechnology
2019 Volume.29 No. 2 p.179 ~ p.190
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Bacillus subtilis Spore Surface Display Technology: A Review of Its Development and Applications
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Zhang Guoyan
An Ying feng
Zabed Hossain M.
Guo Qi
Yang Miaomiao
Yuan Jiao
Li Wen
Sun Wenjin
Qi Xianghui
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Abstract
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Bacillus subtilis spore surface display (BSSD) technology is considered to be one of the most promising approaches for expressing heterologous proteins with high activity and stability. Currently, this technology is used for various purposes, such as the production of enzymes, oral vaccines, drugs and multimeric proteins, and the control of environmental pollution. This paper presents an overview of the latest developments in BSSD technology and its application in protein engineering. Finally, the major limitations of this technology and future directions for its research are discussed.
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KEYWORD
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Bacillus subtilis, spore surface display technology, biocatalysis, gene engineering, anchor protein, linker peptide
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